Diffusion coefficients of oxygen and hemoglobin measured by facilitated oxygen diffusion through hemoglobin solutions
نویسندگان
چکیده
منابع مشابه
Hemoglobin-facilitated diffusion of oxygen: interfacial and thickness effects.
The equations of facilitated diffusion were solved numerically for steady state diffusion of oxygen across membranes of hemoglobin and myoglobin. An interfacial resistance was included in the boundary conditions and the dependence of the solutions on membrane thickness and interfacial conductance was studied. The data of Wittenberg on millipore membranes was fitted adequately if a tortuosity fa...
متن کاملOxygen through Hemoglobin Solutions
The steady-state transport of oxygen through hemoglobin solutions was studied to identify the mechanism of the diffusion augmentation observed at low oxygen tensions. A novel technique employing a platinum-silver oxygen electrode was developed to measure the effective diffusion coefficient of oxygen in steady-state transport. The measurements were made over a wider range of hemoglobin and oxyge...
متن کاملThe molecular mechanism of hemoglobin-facilitated oxygen diffusion.
Hemoglobin in solution augments the rate of steady state diffusion of oxygen. The flux of oxygen exceeds the diffusive flux by an amount, the facilitated flux, which is constant for a given hemoglobin concentration and is invariant with changing oxygen tension. The facilitated flux is inversely proportional to the length of the diffusion path. Facilitation decreases with increasing molecular si...
متن کاملThe Steady-State Transport of Oxygen through Hemoglobin Solutions
The steady-state transport of oxygen through hemoglobin solutions was studied to identify the mechanism of the diffusion augmentation observed at low oxygen tensions. A novel technique employing a platinum-silver oxygen electrode was developed to measure the effective diffusion coefficient of oxygen in steady-state transport. The measurements were made over a wider range of hemoglobin and oxyge...
متن کاملHemoglobin-based oxygen carriers
Transfusable fluids that may be used as alternatives to red blood cell transfusion offer the promise of preserving tissue perfusion and minimizing hypoxic cellular damage, and this promise may soon be fulfilled. Clinical testing of hemoglobin-based oxygen carriers has faced and met challenges involving molecular design, safety, efficacy, and regulatory requirements. Three leading candidates hav...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology
سال: 1997
ISSN: 0167-4838
DOI: 10.1016/s0167-4838(96)00197-5